Indicators on phenobarbital sodium obat apa You Should Know
Indicators on phenobarbital sodium obat apa You Should Know
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pentobarbital will decrease the extent or effect of erlotinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
pentobarbital will reduce the level or effect of lorlatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will reduce the level or effect of docetaxel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified.
pentobarbital will decrease the extent or effect of ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Solid CYP3A4 inducers may decrease partiaprevir and ritonavir amounts, and for that reason lowered efficacy of Viekira Pak
pentobarbital will increase toxicity of buprenorphine, lengthy-acting injection by pharmacodynamic synergism. Modify Therapy/Observe Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants raises danger of adverse reactions which include overdose, respiratory despair, and Demise. Cessation of benzodiazepines or other CNS depressants is preferred in most cases.
pentobarbital will minimize the extent or effect of roflumilast by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration not advisable; potent cytochrome P450 enzyme inducers decrease systemic publicity to roflumilast and could lessen the therapeutic effectiveness
Exclusive patient population: Dosage need to be lessened inside the elderly or debilitated mainly because these people could possibly be extra delicate to barbiturates. Dosage should be decreased for sufferers with impaired renal function or hepatic condition.
pentobarbital will lower the extent or effect of flurbiprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Insignificant/Significance Unknown.
pentobarbital will increase the stage or effect of clopidogrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
fentanyl intranasal and pentobarbital equally enhance sedation. Keep away from or Use Alternate Drug. Limit use to clients for whom alternative cure selections are insufficient
pentobarbital will lessen the extent or effect of tacrolimus by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will decrease the extent or effect of clarithromycin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified.
Observe Closely (one)pentobarbital will minimize the level or effect of benzhydrocodone/acetaminophen by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Caution when discontinuing CYP3A4 inducers that are coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone might improve and may end up in perhaps fatal respiratory despair.
pentobarbital will decrease the extent or effect of fruquintinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use check here Alternate Drug. If coadministration with moderate CYP3A4 inducers is unavoidable, continue to administer fruquintinib at recommended dosage.